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Safeguarding Your Sexual Health with Doxycycline Post-Exposure Prophylaxis (DoxyPEP)


DoxyPEP stands as a powerful tool in the fight against STIs

Sexually transmitted infections (STIs) continue to pose a significant public health concern in 2024, affecting millions of individuals annually. Despite advancements in treatment, some STIs can have lasting impacts on health, emphasizing the importance of preventative measures. One promising preventive treatment is doxycycline post-exposure prophylaxis (DoxyPEP).

This regimen involves taking a course of doxycycline antibiotics within 72 hours of potential STI exposure. Recent studies, including one funded by the National Institutes of Health (NIH), have highlighted its efficacy. DoxyPEP has been found to reduce the risk of contracting certain STIs by an impressive 65% to 88%. Notably, individuals who paired DoxyPEP with other preventative or care regimens saw an increase in its effectiveness.

According to the CDC as of 2022, the impact of STIs in the US remains substantial. There were 1,649,716 reported cases of chlamydia, 648,056 reported cases of gonorrhea, and 203,500 reported cases of syphilis. These statistics underscore the urgent need for effective prevention strategies. Those between the ages of 15-24 accounted for almost half of the newly reported STIs inclusive of HPV, herpes, trichomoniasis, chlamydia, HIV, gonorrhea, syphilis, and hepatitis.

DoxyPEP stands as a powerful tool in the fight against STIs. While it’s essential to acknowledge its limitations and consult healthcare providers for personalized guidance, DoxyPEP offers significant potential in safeguarding sexual health. Reach out to  your doctor to learn more about DoxyPEP and see if it’s suitable for you.” – Douglas Steele, Director of Medical Care Services  

How DoxyPEP Works:

Doxycycline, an antibiotic, impedes the multiplication and spread of bacteria within the body. When used as post-exposure prophylaxis, it can prevent the establishment of infection by bacteria responsible for specific STIs. By initiating doxycycline treatment promptly after potential exposure, individuals can significantly decrease their likelihood of contracting an infection. Keep in mind this is just one tool to combat the contraction of chlamydia, gonorrhea, and syphilis.

Risks and Side Effects:

Like any medication, DoxyPEP carries risks and potential side effects. While most individuals may only experience mild side effects such as nausea, vomiting, or diarrhea, some may encounter more severe reactions like allergic responses, skin rashes, or liver damage. Before taking DoxyPEP, it’s crucial to discuss medical history and current medications with a healthcare provider.

Who Should Consider DoxyPEP:

DoxyPEP is an option for predominantly men who have potentially been exposed to an STI, including those who have engaged in unprotected sex with an infected partner or individuals who have experienced sexual assault. While it’s acknowledged that DoxyPEP isn’t as effective as barrier methods like condoms or dental dams, it can complement these strategies as an additional preventative measure.

DoxyPEP’s Effectiveness:

Studies have demonstrated for the average user it reduced the risk of chlamydia, gonorrhea, and syphilis by 65% to 70%. It also showed effectiveness in reducing the risk of STI when used alongside HIV PrEP, reductions of 87% for syphilis, 88% for chlamydia, and 55% for gonorrhea were observed. Similarly, among individuals with HIV, reductions of 77% for syphilis, 74% for chlamydia, and 57% for gonorrhea were reported.

About Care Resource: Care Resource is a 501(c) (3) nonprofit organization and a Federally Qualified Health Center (FQHC) with locations in Midtown Miami, Little Havana, Miami Beach, and Fort Lauderdale. The health center provides comprehensive health and support services to address the full healthcare needs of South Florida’s pediatric, adolescent, and adult populations.

For media inquiries, please contact Jonathan Welsh, Associate Director of Communications and Development at

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