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Doxycycline Post-Exposure Prophylaxis (DoxyPEP)


DoxyPEP, an Effective Way to Prevent STIs

Sexually transmitted infections (STIs) are widespread and affect millions of people each year. While some STIs can be treated with antibiotics or antiviral medication, others are more serious and can have long-lasting impacts on a person’s health. That’s why it’s important to take preventative measures to reduce your risk of contracting an STI.

Doxycycline post-exposure prophylaxis (DoxyPEP) is a preventative treatment that can reduce the risk of acquiring certain STIs. This treatment involves taking a course of doxycycline antibiotics within 72 hours of potential exposure to an STI. According to a National Institutes of Health (NIH) funded study, DoxyPEP has been shown to be more than 60% effective in reducing the transmission of STIs such as chlamydia, gonorrhea, and syphilis.

How DoxyPEP Works

Doxycycline is a type of antibiotic that can help prevent bacteria from multiplying and spreading within the body. When used for post-exposure prophylaxis, doxycycline can prevent the bacteria responsible for certain STIs from establishing an infection in the body. By taking doxycycline within 72 hours of potential exposure to an STI, you can significantly reduce the likelihood of contracting an infection.

Risks and Side Effects

As with any medication, there are risks and potential side effects associated with DoxyPEP. Some people may experience mild side effects such as nausea, vomiting, or diarrhea. Others may experience more severe side effects such as an allergic reaction, skin rash, or liver damage. It’s important to talk to your healthcare provider about your medical history and any medications you’re currently taking before starting DoxyPEP.

Who Should Consider DoxyPEP?

Doxycycline post-exposure prophylaxis is an option for anyone who has been potentially exposed to an STI. This could include individuals who have had unprotected sex with a partner who has an STI or those who have experienced sexual assault. While DoxyPEP is not as effective as using barrier methods such as condoms or dental dams, it can be a useful preventative measure in addition to these methods.

Doxycycline post-exposure prophylaxis (DoxyPEP) can be a powerful tool in the fight against sexually transmitted infections. While it’s important to remember that doxy-PEP is not a foolproof method of prevention, it can be a valuable option to help protect your sexual health. Talk to one of our healthcare providers today to learn more about DoxyPEP and see if it’s right for you.

About Care Resource:
Care Resource is a 501(c) (3) nonprofit organization and a Federally Qualified Health Center (FQHC) with four locations in Midtown Miami, Little Havana, Miami Beach, and Fort Lauderdale. The health center provides comprehensive health and support services to address the full health care needs of South Florida’s pediatric, adolescent, and adult populations.

For media inquiries, please contact Jonathan Welsh, Associate Director of Communications and Development at

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